H2 influenza viruses: designing vaccines against future H2 pandemics.
Identifieur interne : 000007 ( 1957/Analysis ); précédent : 000006; suivant : 000008H2 influenza viruses: designing vaccines against future H2 pandemics.
Auteurs : Z Beau Reneer [États-Unis] ; Ted M. Ross [États-Unis]Source :
- Biochemical Society transactions [ 1470-8752 ] ; 2019.
Descripteurs français
- KwdFr :
- Acide N-acétyl-neuraminique (métabolisme), Animaux, Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe chez les oiseaux (), Grippe chez les oiseaux (épidémiologie), Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (transmission), Humains, Oiseaux, Pandémies (), Sites de fixation, Sous-type H2N2 du virus de la grippe A (immunologie), Suidae, Vaccins antigrippaux (biosynthèse).
- MESH :
- biosynthèse : Vaccins antigrippaux.
- immunologie : Grippe humaine, Sous-type H2N2 du virus de la grippe A.
- métabolisme : Acide N-acétyl-neuraminique, Glycoprotéine hémagglutinine du virus influenza.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine.
- Animaux, Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Grippe humaine, Humains, Oiseaux, Pandémies, Sites de fixation, Suidae.
English descriptors
- KwdEn :
- Animals, Binding Sites, Birds, Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (biosynthesis), Influenza in Birds (epidemiology), Influenza in Birds (prevention & control), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (transmission), N-Acetylneuraminic Acid (metabolism), Pandemics (prevention & control), Swine.
- MESH :
- chemical , biosynthesis : Influenza Vaccines.
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, N-Acetylneuraminic Acid.
- epidemiology : Influenza in Birds.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza, Human.
- prevention & control : Influenza in Birds, Influenza, Human, Pandemics.
- transmission : Influenza, Human.
- Animals, Binding Sites, Birds, Humans, Swine.
Abstract
Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'Asian Flu' pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world's population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.
DOI: 10.1042/BST20180602
PubMed: 30647144
Affiliations:
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pubmed:30647144Le document en format XML
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<term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term>
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<front><div type="abstract" xml:lang="en">Influenza-related pathologies affect millions of people each year and the impact of influenza on the global economy and in our everyday lives has been well documented. Influenza viruses not only infect humans but also are zoonotic pathogens that infect various avian and mammalian species, which serve as viral reservoirs. While there are several strains of influenza currently circulating in animal species, H2 influenza viruses have a unique history and are of particular concern. The 1957 'Asian Flu' pandemic was caused by H2N2 influenza viruses and circulated among humans from 1957 to 1968 before it was replaced by viruses of the H3N2 subtype. This review focuses on avian influenza viruses of the H2 subtype and the role these viruses play in human infections. H2 influenza viral infections in humans would present a unique challenge to medical and scientific researchers. Much of the world's population lacks any pre-existing immunity to the H2N2 viruses that circulated 50-60 years ago. If viruses of this subtype began circulating in the human population again, the majority of people alive today would have no immunity to H2 influenza viruses. Since H2N2 influenza viruses have effectively circulated in people in the past, there is a need for additional research to characterize currently circulating H2 influenza viruses. There is also a need to stockpile vaccines that are effective against both historical H2 laboratory isolates and H2 viruses currently circulating in birds to protect against a future pandemic.</div>
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